Articles | Supplemental Data | Book Chapters

1. Godfrey, T. E. , Ikebuchi, M., Reynolds, R. J., and Hill, C. K. Characterization of a mammalian cell line that exhibits spontaneous and ultraviolet light-induced hypermutability while retaining resistance to cell killing by ultraviolet light. Int.J.Radiat.Biol., 67: 661-670, 1995. [pdf]
2. Godfrey, T. E. , Cher, M. L., Chhabra, V., and Jensen, R. H. Allelic imbalance mapping of chromosome 16 shows two regions of common deletion in prostate adenocarcinoma. Cancer Genet.Cytogenet., 98: 36-42, 1997. [pdf]
3. Collins, C., Rommens, J. M., Kowbel, D., Godfrey, T., Tanner, M., Hwang, S. I., Polikoff, D., Nonet, G., Cochran, J., Myambo, K., Jay, K. E., Froula, J., Cloutier, T., Kuo, W. L., Yaswen, P., Dairkee, S., Giovanola, J., Hutchinson, G. B., Isola, J., Kallioniemi, O. P., Palazzolo, M., Martin, C., Ericsson, C., Pinkel, D., Gray, J. W., and . Positional cloning of ZNF217 and NABC1: genes amplified at 20q13.2 and overexpressed in breast carcinoma. Proc.Natl.Acad.Sci.U.S.A, 95: 8703-8708, 1998. [pdf]
4. Fejzo, M. S., Godfrey, T., Chen, C., Waldman, F., and Gray, J. W. Molecular cytogenetic analysis of consistent abnormalities at 8q12-q22 in breast cancer. Genes Chromosomes.Cancer, 22: 105-113, 1998. [pdf]
5. Hiraguri, S., Godfrey, T., Nakamura, H., Graff, J., Collins, C., Shayesteh, L., Doggett, N., Johnson, K., Wheelock, M., Herman, J., Baylin, S., Pinkel, D., and Gray, J. Mechanisms of inactivation of E-cadherin in breast cancer cell lines. Cancer Res., 58: 1972-1977, 1998. [pdf]
6. Kim, S. H., Godfrey, T., and Jensen, R. H. Whole genome amplification and molecular genetic analysis of DNA from paraffin-embedded prostate adenocarcinoma tumor tissue. J.Urol., 162: 1512-1518, 1999.
7. Shayesteh, L., Lu, Y., Kuo, W. L., Baldocchi, R., Godfrey, T., Collins, C., Pinkel, D., Powell, B., Mills, G. B., and Gray, J. W. PIK3CA is implicated as an oncogene in ovarian cancer. Nat.Genet., 21: 99-102, 1999.
8. Godfrey, T. E. , Kim, S. H., Chavira, M., Ruff, D. W., Warren, R. S., Gray, J. W., and Jensen, R. H. Quantitative mRNA expression analysis from formalin-fixed, paraffin- embedded tissues using 5' nuclease quantitative reverse transcription- polymerase chain reaction. J.Mol.Diagn., 2: 84-91, 2000. [pdf]
9. Raja, S., Luketich, J. D., Kelly, L. A., Ruff, D. W., and Godfrey, T. E. Increased sensitivity of one-tube, quantitative RT-PCR. Biotechniques, 29: 702, 704, 706, 2000.
10. Ginzinger, D. G., Godfrey, T. E., Nigro, J., Moore, D. H., Suzuki, S., Pallavicini, M. G., Gray, J. W., and Jensen, R. H. Measurement of DNA copy number at microsatellite loci using quantitative PCR analysis. Cancer Res., 60: 5405-5409, 2000. [pdf]
11. Suzuki, S., Moore, D. H., Ginzinger, D. G., Godfrey, T. E., Barclay, J., Powell, B., Pinkel, D., Zaloudek, C., Lu, K., Mills, G., Berchuck, A., and Gray, J. W. An approach to analysis of large-scale correlations between genome changes and clinical endpoints in ovarian cancer. Cancer Res., 60: 5382-5385, 2000. [pdf]
12. Tassone, F., Hagerman, R. J., Taylor, A. K., Gane, L. W., Godfrey, T. E., and Hagerman, P. J. Elevated levels of FMR1 mRNA in carrier males: a new mechanism of involvement in the fragile-X syndrome. Am.J.Hum.Genet., 66: 6-15, 2000. [pdf]
13. Moore, L., Godfrey, T., Eng, C., Smith, A., Ho, R., and Waldman, F. M. Validation of fluorescent SSCP analysis for sensitive detection of p53 mutations. Biotechniques, 28: 986-992, 2000.
14. Weiss, W. A., Godfrey, T., Francisco, C., and Bishop, J. M. Genome-wide screen for allelic imbalance in a mouse model for neuroblastoma. Cancer Res., 60: 2483-2487, 2000.
15. Bastian, B. C., Kashani-Sabet, M., Hamm, H., Godfrey, T., Moore, D. H., Brocker, E. B., LeBoit, P. E., and Pinkel, D. Gene amplifications characterize acral melanoma and permit the detection of occult tumor cells in the surrounding skin. Cancer Res., 60: 1968-1973, 2000.
16. Godfrey, T. E. , Raja, S., Finkelstein, S. D., Gooding, W. E., Kelly, L. A., and Luketich, J. D. Prognostic value of quantitative reverse transcription-polymerase chain reaction in lymph node-negative esophageal cancer patients. Clin.Cancer Res., 7: 4041-4048, 2001. [pdf]
17. Raja, S., Finkelstein, S. D., Baksh, F. K., Gooding, W. E., Swalsky, P. A., Godfrey, T. E., Buenaventura, P. O., and Luketich, J. D. Correlation between dysplasia and mutations of six tumor suppressor genes in Barrett's esophagus. Ann.Thorac.Surg., 72: 1130-1135, 2001.
18. Simmons, M. L., Lamborn, K. R., Takahashi, M., Chen, P., Israel, M. A., Berger, M. S., Godfrey, T., Nigro, J., Prados, M., Chang, S., Barker, F. G., and Aldape, K. Analysis of complex relationships between age, p53, epidermal growth factor receptor, and survival in glioblastoma patients. Cancer Res., 61: 1122-1128, 2001.
19. Raja, S., Luketich, J. D., Kelly, L. A., Gooding, W. E., Finkelstein, S. D., and Godfrey, T. E. Rapid, quantitative reverse transcriptase-polymerase chain reaction: application to intraoperative molecular detection of occult metastases in esophageal cancer. J.Thorac.Cardiovasc.Surg., 123: 475-482, 2002. [pdf]
20. Aldape, K., Ginzinger, D. G., and Godfrey, T. E. Real-time quantitative polymerase chain reaction: a potential tool for genetic analysis in neuropathology. Brain Pathol., 12: 54-66, 2002.
21. Rajs.S., El-Hefnawy, T., Kelly, L. A., Chestney, M., Luketich, J. D., and Godfrey, T. E. A temperature controlled primer limit for multiplexing of rapid, quantitative RT-PCR assays: Application to intra-operative cancer diagnostics. Clinical Chemistry Vol. 48 Issue 8, 2002. [pdf]
22. Huang, X., Gollin, S. M., Raja, S., and Godfrey, T. E. High resolution mapping of the 11q13 amplicon and identification of a new gene, TAOS1, that is amplified and overexpressed in oral cancer cells. Proc.Natl.Acad.Sci.U.S.A . Vol.99 Issue 17: 2002. [pdf]
23. Raja, S., Godfrey, T.E. and Luketich, J.D. The role of tumor suppressor genes in esophageal cancer. Minerva Chir. 2002 Dec;57(6):767-80. Review. [pdf]
24. Collins, J. L., Vodovotz, Y., Hierholzer, C., Villavicencio, R. T., Liu, S., Alber, S., Gallo, D., Stoltz, D. B., Watkins, S. C., Godfrey, T. E., Gooding, W. E., Kelly, E., Peitzman, A. B., and Billiar, T. R. Characterization of the Expression of Inducible Nitric Oxide Synthase in Rat and Human Liver during Hemorrhagic Shock. Shock, 19: 117-122, 2003.
25. Makhija, S., Sit, A., Edwards, R., Aufman, K., Weiss, H., Kanbour-Shakir, A., Gooding, W., D'Angelo, G., Ferrell, R., Raja, S., and Godfrey, T. E. Identification of Genetic Alterations Related to Chemoresistance in Epithelial Ovarian Cancer. Gynecologic Oncology, 90: p3-9, 2003. [pdf]
26. El-Hefnawy, T., Raja, S., Kelly, L.A., Bigbee, W.L., Kirkwood, J.M., Luketich, J.D. and Godfrey, T.E. Characterization of Amplifiable, Circulating RNA in Plasma and its Potential as a Tool for Cancer Diagnostics. Clinical Chemistry; 50: 564 – 573, 2004. [pdf]
27. Coello, M., Luketich, J.D., Litle, V.R., Godfrey, T.E. Prognostic Significance of Micrometastasis in Non-Small Cell Lung Cancer. Clinical Lung Cancer, 5 (4); 214-225, 2004. [pdf]
28. Wang, J., Xi, L., Hunt, J.L., Whiteside, T.L., Godfrey, T.E. and Ferris, R.L. Coordinate Expression of Chemokine Receptor 6 (CCR6) and CCR7 in Squamous Cell Carcinoma of the Head and Neck – Identification of a Metastatic Phenotype. Cancer Research: 64, 1861-1866, 2004. [pdf]
29. Lyons-Weiler J, Patel S, Becich MJ, Godfrey TE. Tests for Finding Complex Patterns of Differential Expression in Cancers: Towards Individualized Medicine. BMC Bioinformatics. 2004 Aug 12;5(1):110 [pdf]
30. Luis J. Herrera, Siva Raja, William E. Gooding, Talal El-Hefnawy, Lori Kelly, James D. Luketich and Tony E. Godfrey. Quantitative Analysis of Circulating Plasma DNA Levels as a Tumor Marker in Thoracic Malignancies. Clinical Chemistry, 51(1): 113-118, 2005. [pdf]
31. Wang J, Xi L, Gooding W, Godfrey TE, Ferris RL. Chemokine receptors 6 and 7 identify a metastatic expression pattern in squamous cell carcinoma of the head and neck. Adv Otorhinolaryngol. 2005; 62:121-33. [pdf]
32. Xi, L, Luketich, JD, Raja, S, Gooding, W, Litle, VR, Coello, MC, Finkelstein, SD, Chestney, ML, Landreneau, RJ, Hughes SJ, Godfrey, TE. Molecular Staging of Lymph Nodes from Patients with Esophageal Adenocarcinoma. Clinical Cancer Research 2005; Feb 1;11(3):1099-109. [pdf] [Supplemental Data: Supplemental Table 1 [pdf] | Supplemental Table 2 [pdf] | Supplemental Methods [pdf] ]
33. Luis J. Herrera, Talal El-Hefnawy, Pierre E. Queiroz de Oliveira , Siva Raja, Sydney Finkelstein,William Gooding, James D. Luketich, Tony E. Godfrey and Steven J. Hughes. The HGF Receptor c-Met Is Overexpressed in Esophageal Adenocarcinoma. Neoplasia 2005 Jan;7(1):75-84
34. Michael T. Lotze, Ena Wang, Francesco M. Marincola, Nabil Hanna, Peter J. Bugelski, Christine A. Burns, George Coukos, Nitin Damle, Tony E. Godfrey, W. Martin Howell, Monica C. Panelli, Michael A. Perricone, Emanuel F. Petricoin, Guido Sauter, Carmen Scheibenbogen, Steven C. Shivers, D. Lansing Taylor, John N. Weinstein, and Theresa L. Whiteside.Report from the International Society for the Biologic Therapy of Cancer Workshop on Cancer Biometrics: Identifying Biomarkers and Surrogates of Tumors in Patients. J. Immunother. 2005 March/April; 28(2):79-119. [pdf]
35. Robert L. Ferris, Liqiang Xi , Siva Raja, Jennifer L. Hunt , Jun Wang, William E. Gooding, Lori Kelly, Jesus Ching, James D. Luketich, Tony E. Godfrey. Molecular Staging of Cervical Lymph Nodes in Squamous Cell Carcinoma of the Head and Neck. Cancer Research 2005 Mar 15;65(6):2147-56. [pdf] [Supplemental Data: Supplemental Table 1 [pdf] | Supplemental Figure 1 [pdf] | Supplemental Figure 2 [pdf]]
36. Liqiang Xi, James Lyons-Weiler, Michael C. Coello, Xin Huang, William E. Gooding, James D. Luketich, Tony E. Godfrey. Prediction of Lymph Node Metastasis by analysis of Gene Expression Profiles in Primary Lung Adenocarcinomas. Clinical Cancer Research 2005 Jun 1;11(11):4128-35. [pdf] [Supplemental Data [xls] | Supplemental Figure 1 [gif] | Supplemental Figure 2 [gif]]
37. Siva Raja, Jesus Ching, Liqiang Xi, Steven J. Hughes, Ronald Chang, Wendy Wong, William McMillan, William E. Gooding, Kenneth S. McCarty Jr., Melissa Chestney, James D. Luketich, and Tony E. Godfrey. A New Technology for Automated, Rapid, and Quantitiative PCR or RT-PCR Clinical Testing. Clinical Chemistry 2005; 51:5. [pdf]
38. Steven J. Hughes, Liqiang Xi, Siva Raja, William Gooding, David J. Cole, William E. Gillanders, Keidi Mikhitarian, Kenneth McCarty, Susan Silver, Jesus Ching, William McMillan, James D. Luketich, and Tony E. Godfrey. A Rapid, Fully-Automated, Molecular-Based Assay Accurately Analyzes Sentinel Lymph Nodes for the Presence of Metastatic Breast Cancer. Review; Annals of Surgery 2006; 243: 389–398 .
39. Kuss I, Godfrey T, Donnenberg AD, RL Ferris, JM Harris, W Gooding and TL Whiteside. Low thymic output and/or rapid lymphocyte turnover in the circulation of patients with cancer. Recent thymic emigrants and subsets of naïve and memory T cells. Clin Immunol. 2005 Jul;116(1):27-36. [pdf]
40. Liqiang Xi, William Gooding, Kenneth McCarty, Tony E. Godfrey, and Steven J. Hughes. Identification of mRNA Markers for Molecular Staging of Lymph Nodes in Colorectal Cancer. Clinical Chemistry 2006; 52: 520-523. [pdf] | Supplemental Data Table 1 [doc] | Supplemental Data Table 2 [doc] | Supplemental Data Figure 1 [ppt] | Figure legend for Supplemental Data Figure 1 [doc].
41. Liqiang Xi, Michael C. Coello, Virginia R. Litle, Siva Raja, William E. Gooding, Samuel A. Yousem, Talal El-Hefnawy, Rodney J. Landreneau, James D. Luketich, and Tony E. Godfrey. A Combination of Molecular Markers Accurately Detects Lymph Node Metastasis in NSCLC Patients. Clinical Cancer Research 2006; in press. | Supplemental Tables [doc] | Supplemental Figure 1 [ppt] | Figure legend for Supplemental Data Figure 1 [doc].
42. Liqiang Xi, Michael C. Coello, Virginia R. Litle, Siva Raja, William E. Gooding, Samuel A.Yousem, Talal El-Hefnawy, Rodney, J. Landreneau, James D. Luketich, and Tony E. Godfrey  A Combination of Molecular Markers Accurately Detects Lymph Node Metastasis in NSCLC Patients. Clin.Cancer Res., 12: 2484-2491, 2006.
43. Xin Huang, Tony E. Godfrey, William E. Gooding, Kenneth S. McCarty and Susanne M. Gollin Comprehensive Genome and Transcriptome Analysis of the 11q13 Amplicon in Oral Cancer and Synteny to the 7F5 Amplicon in Murine Oral Carcinoma. Genes Chromosomes Cancer. 2006 Nov;45(11):1058-69.
44. Liqiang Xi, Daniel G. Nicastri, Talal El-Hefnawy, Steven J. Hughes, James D. Luketich, Tony E. Godfrey. Optimal Markers for Real-Time Quantitative Reverse Transcription PCR Detection of Circulating Tumor Cells from Melanoma, Breast, Colon, Esophageal, Head and Neck, and Lung Cancers. 2007 Clinical Chemistry, 53(7).
45. Daniel Nicastri, Tony E. Godfrey and Stephen J. Hughes. Is Occult Lymph Node Disease in Colorectal Cancer Patients Clinically Significant?  A Review of the Relevant Literature. Journal of Molecular Diagnostics; 2007 Nov;9(5):563-71.
46. MicroRNA Expression Profiles of Esophageal Cancer. Andrew Feber PhD, Liqiang Xi MD, James D. Luketich MD, Arjun Pennathur MD, Rodney J. Landreneau MD, Maoxin Wu MD, Scott J. Swanson MD, Tony E. Godfrey PhD, Virginia R. Litle MD. Journal of Thoracic and Cardiovascular Surgery; 2008 Feb;135(2):255-60.
47. Identification of cancer-related genes that are alternatively spliced at high frequency in lung adenocarcinoma. Xi, L., Feber, A., Gupta, V. K., Wu, M., Landreaneau, R. J., Litle, V. R., Luketich, J., and Godfrey, T. E. Nucleic Acids Research, October 16 2008 (Epub ahead of print).
48. Molecular Staging of Pathologically Negative Sentinel Lymph Nodes from Melanoma Patients using Multimarker, Quantitative Real Time RT-PCR. Josep M. Hilari, Cristina Mangas, Liqiang Xi, Cristina Paradelo, Carlos Ferrándiz, Steven J. Hughes, Cindy Yueh, Ivy Altomare, William E. Gooding and Tony E. Godfrey. In Press, Annals of Surgical Oncology 2008.
49. CCND1 G/A870 Polymorphism Does Not Determine Cyclin D1 Variant Expression in Esophageal Adenocarinoma or Non-Small Cell Lung Cancer. Vanita K. Gupta, Andrew Feber, Liqiang Xi, Arjun Pennathur, Maoxin Wu, James D Luketich, Tony E. Godfrey. In Press; Clinical Cancer Research 2008.
50. Integrated Genomic Analysis Identifies Therapeutic Targets and Prognostic Markers in Esophageal Adenocarcinoma.  Andrew Feber, Liqiang Xi, Arjun Pennathur, James D. Luketich, Weijia Zhang, Yezhou Sun, Daniel Nicastri, Maoxin Wu, Vanita Gupta, Scott J. Swanson, William E. Gooding, Virginia R. Litle, and Tony E. Godfrey. In review.
51. A QRT-PCR Assay for Rapid Analysis of Breast Cancer Sentinel Lymph Nodes. Steven J. Hughes, MD, Liqiang Xi, MD, William Gooding, MS, David J. Cole, MD, John Metcalf, MD, Michael Mitas, PhD, Rohit Bhargava, MD, David Dabbs, MD, Jesus Ching, PhD, William McMillan, PhD, and Tony E. Godfrey, PhD. In Review.
52. Molecular Staging of Occult Nodal Metastases in Esophageal Adenocarcinoma is Predictive of Worse Clinical Outcomes. Ivy Altomare, Arjun Pennathur, Liqiang Xi, Virginia R. Litle, William E. Gooding, James D. Luketich and Tony E. Godfrey. Manuscript in preparation.
53. MicroRNA Expression Profiles predict outcome in Esophageal Adenocarcinoma. Feber, A., Xi, L., Luketich, J. D., Pennathur, A, Landreaneau, R., Wu, M. H., Swanson S.J, Litle, V.R and Godfrey, T.E. Manuscript in Preparation.

Book Chapters:

1. Hill, C. K. and Godfrey, T. E. Adaptive responses after exposure to low dose radiation. In Edward J.Calabrese (ed.), Biological effects of low level exposures: Dose response relationships., pp. 255-270. Lewis Publishers, 1994.
2. Development of Quantitative RT-PCR Assays for Measuring Gene Expression Tony E. Godfrey and Lori A. Kelly. Molecular Toxicology Protocols, Humana Press, 2004. [pdf]
3. Godfrey T.E. Intraoperative Molecular Staging of Lymph Nodes. Molecular Foundations in Pathology Series.  2008.

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