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Tony E. Godfrey, Ph.D.
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Current Position Associate Professor of Surgery
University of Rochester Medical Center
Rochester, NY.
Professional Address James P. Wilmot Cancer Center
601 Elmwood Avenue
Box 704
Rochester, NY 14642.
Education 1994 Ph.D. IN MOLECULAR BIOLOGY/BIOCHEMISTRY.
Brunel University, England (research was carried out at the University of Southern California, Los Angeles).
  1989 B.Sc. HONORS DEGREE IN BIOCHEMISTRY.
Brunel University, England.
Academic
Appointments

2008-present Associate Professor of Surgery, University of Rochester Medical Center,
Rochester, NY.

2004-2008. Associate Professor of Pathology, Mount Sinai School of medicine, New York, NY.

2004-Present. Adjunct Assistant Professor of Surgery, University of Pittsburgh.

July 2004-Present. Associate Professor of Surgery and Biomedical Genetics, Mount Sina School of medicine, New York, NY.

1999- 2004. Assistant Professor of Surgery and Human Genetics, University of Pittsburgh

1999- 2004. Director, University of Pittsburgh Cancer Institute TaqMan Core Facility.

1997-1999. Research specialist and Manager of the Genome Analysis Core Facility at UCSF.

1995-1997. Post Doctoral Fellow in the laboratory of Dr. Joe Gray at UCSF.

1993-1995. Post Doctoral Fellow in the laboratory of Dr. Ron Jensen at UCSF.

1989-1993. Graduate student with Dr. Colin Hill at the University of Southern California.

Other Employment/
Appointments
2002-2006. Scientific Advisory Board, Cepheid, Sunnyvale CA.
Review Activities

Grants:
NIH/NCI
2004 Reviewer for ZRG1 special emphasis panel, September 2004.
2005 Reviewer for “Innovative Technologies for Molecular Analysis of Cancer” June 14-15, 2005.

NCIC (National Cancer Institute of Canada)
2008 Head and neck cancer program project reviewer

Other
2003 and 2004- External grant reviewer for the South Carolina Research Centers of Economic Excellence Endowed Professorship Program

Journals:
Ad-hoc reviewer for Biotechniques
Ad-hoc reviewer for Clinical Chemistry
Ad-hoc reviewer for Journal of Molecular Diagnostics
Ad-hoc reviewer for European Journal of Cancer
Ad-hoc reviewer for Head and Neck
Ad-hoc reviewer for Cancer Letters
Ad-hoc reviewer for Oncogene
Ad-hoc reviewer for Clinical Cancer Research
Ad-hoc reviewer for Diseases of the Esophagus
Ad-hoc reviewer for Journal of Hepatology
Ad-hoc reviewer for Cancer Research
Ad-hoc reviewer for the Journal of Thoracic and Cardiovascular Surgery
Ad-hoc reviewer for PNAS

Teaching/Mentoring Siva Raja, M.D./Ph.D., Graduate Student, 1999-2003.
Luis Herrera, M.D., Surgery Resident Research Fellow, 2001-2002.
Michael Coello, M.D., Surgery Resident Research Fellow, 2002-2004.
Melissa Chestney, BS., Summer Student, 2001.
Xin Huang, Ph.D. Graduate student and Post Doctoral Fellow 2000-2004
Danial Nicastri, M.D., Surgery Resident Research Fellow 2005-2006
Cristina Mangas, M.D., Visiting fellow 2005-2006
Ivy Altomare, M.D., Medical Oncology Research Fellow 2006-Present
Jon Chan, BS., Medical student 2006-present
Andrew Feber, Ph.D. Post-doctoral fellow 2005-2008
Vanita Gupta, Ph.D. Post Doctoral Fellow 2006-2008
Publications
  1. Godfrey, T. E., Ikebuchi, M., Reynolds, R. J., and Hill, C. K. Characterization of a mammalian cell line that exhibits spontaneous and ultraviolet light-induced hypermutability while retaining resistance to cell killing by ultraviolet light. Int.J.Radiat.Biol., 67: 661-670, 1995.
  2. Godfrey, T. E., Cher, M. L., Chhabra, V., and Jensen, R. H. Allelic imbalance mapping of chromosome 16 shows two regions of common deletion in prostate adenocarcinoma. Cancer Genet.Cytogenet., 98: 36-42, 1997.
  3. Collins, C., Rommens, J. M., Kowbel, D., Godfrey, T., Tanner, M., Hwang, S. I., Polikoff, D., Nonet, G., Cochran, J., Myambo, K., Jay, K. E., Froula, J., Cloutier, T., Kuo, W. L., Yaswen, P., Dairkee, S., Giovanola, J., Hutchinson, G. B., Isola, J., Kallioniemi, O. P., Palazzolo, M., Martin, C., Ericsson, C., Pinkel, D., Gray, J. W., and . Positional cloning of ZNF217 and NABC1: genes amplified at 20q13.2 and overexpressed in breast carcinoma. Proc.Natl.Acad.Sci.U.S.A, 95: 8703-8708, 1998.
  4. Fejzo, M. S., Godfrey, T., Chen, C., Waldman, F., and Gray, J. W. Molecular cytogenetic analysis of consistent abnormalities at 8q12-q22 in breast cancer. Genes Chromosomes.Cancer, 22: 105-113, 1998.
  5. Hiraguri, S., Godfrey, T., Nakamura, H., Graff, J., Collins, C., Shayesteh, L., Doggett, N., Johnson, K., Wheelock, M., Herman, J., Baylin, S., Pinkel, D., and Gray, J. Mechanisms of inactivation of E-cadherin in breast cancer cell lines. Cancer Res., 58: 1972-1977, 1998.
  6. Kim, S. H., Godfrey, T., and Jensen, R. H. Whole genome amplification and molecular genetic analysis of DNA from paraffin-embedded prostate adenocarcinoma tumor tissue. J.Urol., 162: 1512-1518, 1999.
  7. Shayesteh, L., Lu, Y., Kuo, W. L., Baldocchi, R., Godfrey, T., Collins, C., Pinkel, D., Powell, B., Mills, G. B., and Gray, J. W. PIK3CA is implicated as an oncogene in ovarian cancer. Nat.Genet., 21: 99-102, 1999.
  8. Godfrey, T. E., Kim, S. H., Chavira, M., Ruff, D. W., Warren, R. S., Gray, J. W., and Jensen, R. H. Quantitative mRNA expression analysis from formalin-fixed, paraffin- embedded tissues using 5' nuclease quantitative reverse transcription- polymerase chain reaction. J.Mol.Diagn., 2: 84-91, 2000.
  9. Raja, S., Luketich, J. D., Kelly, L. A., Ruff, D. W., and Godfrey, T. E. Increased sensitivity of one-tube, quantitative RT-PCR. Biotechniques, 29: 702, 704, 706, 2000.
  10. Ginzinger, D. G., Godfrey, T. E., Nigro, J., Moore, D. H., Suzuki, S., Pallavicini, M. G., Gray, J. W., and Jensen, R. H. Measurement of DNA copy number at microsatellite loci using quantitative PCR analysis. Cancer Res., 60: 5405-5409, 2000.
  11. Suzuki, S., Moore, D. H., Ginzinger, D. G., Godfrey, T. E., Barclay, J., Powell, B., Pinkel, D., Zaloudek, C., Lu, K., Mills, G., Berchuck, A., and Gray, J. W. An approach to analysis of large-scale correlations between genome changes and clinical endpoints in ovarian cancer. Cancer Res., 60: 5382-5385, 2000.
  12. Tassone, F., Hagerman, R. J., Taylor, A. K., Gane, L. W., Godfrey, T. E., and Hagerman, P. J. Elevated levels of FMR1 mRNA in carrier males: a new mechanism of involvement in the fragile-X syndrome. Am.J.Hum.Genet., 66: 6-15, 2000.
  13. Moore, L., Godfrey, T., Eng, C., Smith, A., Ho, R., and Waldman, F. M. Validation of fluorescent SSCP analysis for sensitive detection of p53 mutations. Biotechniques, 28: 986-992, 2000.
  14. Weiss, W. A., Godfrey, T., Francisco, C., and Bishop, J. M. Genome-wide screen for allelic imbalance in a mouse model for neuroblastoma. Cancer Res., 60: 2483-2487, 2000.
  15. Bastian, B. C., Kashani-Sabet, M., Hamm, H., Godfrey, T., Moore, D. H., Brocker, E. B., LeBoit, P. E., and Pinkel, D. Gene amplifications characterize acral melanoma and permit the detection of occult tumor cells in the surrounding skin. Cancer Res., 60: 1968-1973, 2000.
  16. Godfrey, T. E., Raja, S., Finkelstein, S. D., Gooding, W. E., Kelly, L. A., and Luketich, J. D. Prognostic value of quantitative reverse transcription-polymerase chain reaction in lymph node-negative esophageal cancer patients. Clin.Cancer Res., 7: 4041-4048, 2001.
  17. Raja, S., Finkelstein, S. D., Baksh, F. K., Gooding, W. E., Swalsky, P. A., Godfrey, T. E., Buenaventura, P. O., and Luketich, J. D. Correlation between dysplasia and mutations of six tumor suppressor genes in Barrett's esophagus. Ann.Thorac.Surg., 72: 1130-1135, 2001.
  18. Simmons, M. L., Lamborn, K. R., Takahashi, M., Chen, P., Israel, M. A., Berger, M. S., Godfrey, T., Nigro, J., Prados, M., Chang, S., Barker, F. G., and Aldape, K. Analysis of complex relationships between age, p53, epidermal growth factor receptor, and survival in glioblastoma patients. Cancer Res., 61: 1122-1128, 2001.
  19. Raja, S., Luketich, J. D., Kelly, L. A., Gooding, W. E., Finkelstein, S. D., and Godfrey, T. E. Rapid, quantitative reverse transcriptase-polymerase chain reaction: application to intraoperative molecular detection of occult metastases in esophageal cancer. J.Thorac.Cardiovasc.Surg., 123: 475-482, 2002.
  20. Aldape, K., Ginzinger, D. G., and Godfrey, T. E. Real-time quantitative polymerase chain reaction: a potential tool for genetic analysis in neuropathology. Brain Pathol., 12: 54-66, 2002.
  21. Rajs.S., El-Hefnawy, T., Kelly, L. A., Chestney, M., Luketich, J. D., and Godfrey, T. E.  A temperature controlled primer limit for multiplexing of rapid, quantitative RT-PCR assays: Application to intra-operative cancer diagnostics. Clinical Chemistry Vol. 48 Issue 8, 2002.
  22. Huang, X., Gollin, S. M., Raja, S., and Godfrey, T. E.  High resolution mapping of the 11q13 amplicon and identification of a new gene, TAOS1, that is amplified and overexpressed in oral cancer cells. Proc.Natl.Acad.Sci.U.S.A . Vol.99 Issue 17: 2002.
  23. Raja, S., Godfrey, T.E. and Luketich, J.D. The role of tumor suppressor genes in esophageal cancer. Minerva Chir. 2002 Dec;57(6):767-80. Review.
  24. Collins, J. L., Vodovotz, Y., Hierholzer, C., Villavicencio, R. T., Liu, S., Alber, S., Gallo, D., Stoltz, D. B., Watkins, S. C., Godfrey, T. E., Gooding, W. E., Kelly, E., Peitzman, A. B., and Billiar, T. R. Characterization of the Expression of Inducible Nitric Oxide Synthase in Rat and Human Liver during Hemorrhagic Shock. Shock, 19: 117-122, 2003.
  25. Makhija, S., Sit, A., Edwards, R., Aufman, K., Weiss, H., Kanbour-Shakir, A., Gooding, W., D'Angelo, G., Ferrell, R., Raja, S., and Godfrey, T. E. Identification of Genetic Alterations Related to Chemoresistance in Epithelial Ovarian Cancer. Gynecologic Oncology, 90:  p3-9, 2003.
  26. El-Hefnawy, T., Raja, S., Kelly, L.A., Bigbee, W.L., Kirkwood, J.M., Luketich, J.D. and Godfrey, T.E. Characterization of Amplifiable, Circulating RNA in Plasma and its Potential as a Tool for Cancer Diagnostics. Clinical Chemistry; 50: 564 – 573, 2004.
  27. Coello, M., Luketich, J.D., Litle, V.R., Godfrey, T.E. Prognostic Significance of Micrometastasis in Non-Small Cell Lung Cancer. Clinical Lung Cancer, 5 (4); 214-225, 2004.
  28. Wang, J., Xi, L., Hunt, J.L.,  Whiteside, T.L., Godfrey, T.E. and Ferris, R.L. Coordinate Expression of Chemokine Receptor 6 (CCR6) and CCR7 in Squamous Cell Carcinoma of the Head and Neck – Identification of a Metastatic Phenotype. Cancer Research: 64, 1861-1866, 2004.
  29. Lyons-Weiler J, Patel S, Becich MJ, Godfrey TE. Tests for Finding Complex Patterns of Differential Expression in Cancers: Towards Individualized Medicine. BMC Bioinformatics. 2004 Aug 12;5(1):110
  30. Luis J. Herrera, Siva Raja, William E. Gooding, Talal El-Hefnawy, Lori Kelly, James D. Luketich and Tony E. Godfrey. Quantitative Analysis of Circulating Plasma DNA Levels as a Tumor Marker in Thoracic Malignancies. Clinical Chemistry, 51(1): 113-118, 2005.
  31. Wang J, Xi L, Gooding W, Godfrey TE, Ferris RL. Chemokine receptors 6 and 7 identify a metastatic expression pattern in squamous cell carcinoma of the head and neck. Adv Otorhinolaryngol. 2005; 62:121-33.
  32. Xi, L, Luketich, JD, Raja, S, Gooding, W, Litle, VR, Coello, MC, Finkelstein, SD, Chestney, ML, Landreneau, RJ, Hughes SJ, Godfrey, TE. Molecular Staging of Lymph Nodes from Patients with Esophageal Adenocarcinoma. Clinical Cancer Research 2005; Feb 1;11(3):1099-109.
  33. Luis J. Herrera, Talal El-Hefnawy, Pierre E. Queiroz de Oliveira , Siva Raja, Sydney Finkelstein,William Gooding, James D. Luketich, Tony E. Godfrey and Steven J. Hughes. The HGF Receptor c-Met Is Overexpressed in Esophageal Adenocarcinoma. Neoplasia 2005 Jan;7(1):75-84
  34. Michael T. Lotze, Ena Wang,  Francesco M. Marincola,  Nabil Hanna,  Peter J. Bugelski,  Christine A. Burns,  George Coukos,  Nitin Damle,  Tony E. Godfrey,  W. Martin Howell, Monica C. Panelli,  Michael A. Perricone,  Emanuel F. Petricoin,  Guido Sauter,  Carmen Scheibenbogen,  Steven C. Shivers,  D. Lansing Taylor,  John N. Weinstein,  and Theresa L. Whiteside.Report from the International Society for the Biologic Therapy of Cancer Workshop on Cancer Biometrics: Identifying Biomarkers and Surrogates of Tumors in Patients.  J. Immunother. 2005 March/April; 28(2):79-119.
  35. Robert L. Ferris, Liqiang Xi, Siva Raja, Jennifer L. Hunt, Jun Wang, William E. Gooding, Lori Kelly, Jesus Ching, James D. Luketich, Tony E. Godfrey. Molecular Staging of Cervical Lymph Nodes in Squamous Cell Carcinoma of the Head and Neck. Cancer Research 2005 Mar 15;65(6):2147-56.
  36. Liqiang Xi, James Lyons-Weiler, Michael C. Coello, Xin Huang, William E. Gooding, James D. Luketich, Tony E. Godfrey. Prediction of Lymph Node Metastasis by analysis of Gene Expression Profiles in Primary Lung Adenocarcinomas. Clinical Cancer Research 2005 Feb 1;11(3):1099-109.
  37. Siva Raja, Jesus Ching, Liqiang Xi, Steven J. Hughes,  Ronald Chang,  Wendy Wong,  William McMillan,  William E. Gooding,  Kenneth S. McCarty Jr.,  Melissa Chestney,  James D. Luketich,  and  Tony E. Godfrey. A New Technology for Automated, Rapid, and Quantitiative PCR or RT-PCR Clinical Testing. Clinical Chemistry 2005; 51:5.
  38. Kuss I., Schaefer C., Godfrey T.E., Ferris R.L., Harris J.M., Gooding W.E. and Whiteside T.L. Recent thymic emigrants and subsets of naive and memory T cells in the circulation of patients with head and neck cancer. Clinical Immunology 2005 Jul;116(1):27-36.
  39. Steven J. Hughes, Liqiang Xi, Siva Raja, William Gooding, David J. Cole, William E. Gillanders, Keidi Mikhitarian, Kenneth McCarty, Susan Silver, Jesus Ching, William McMillan, James D. Luketich, and Tony E. Godfrey. A Rapid, Fully-Automated, Molecular-Based Assay Accurately Analyzes Sentinel Lymph Nodes for the Presence of Metastatic Breast Cancer.  Annals of Surgery, 2006 Mar;243(3):389-398.
  40. Asif Khalid , Sydney Finkelstein , Bryan Thompson , Lori Kelly, Christoph Hanck, Tony E. Godfrey , David C. Whitcomb.A 93 year old man with the PRSS1 R122H mutation, low SPINK1 expression and without pancreatitis: Insights into phenotypic non-penetrance.  Gut. 2006 May;55(5):728-31
  41. Liqiang Xi, William Gooding, MS, Kenneth McCarty, William McMillan, Tony E. Godfrey, and Steven J. Hughes. Identification of mRNA markers for molecular staging of lymph nodes in colorectal cancer.
    Clin Chem. 2006 Mar;52(3):520-3.
  42. Liqiang Xi, Michael C. Coello, Virginia R. Litle, Siva Raja, William E. Gooding, Samuel A.Yousem, Talal El-Hefnawy, Rodney, J. Landreneau, James D. Luketich, and Tony E. Godfrey  A Combination of Molecular Markers Accurately Detects Lymph Node Metastasis in NSCLC Patients. Clin.Cancer Res., 12: 2484-2491, 2006.
  43. Xin Huang, Tony E. Godfrey, William E. Gooding, Kenneth S. McCarty and Susanne M. Gollin Comprehensive Genome and Transcriptome Analysis of the 11q13 Amplicon in Oral Cancer and Synteny to the 7F5 Amplicon in Murine Oral Carcinoma. Genes Chromosomes Cancer. 2006 Nov;45(11):1058-69.
  44. Liqiang Xi, Daniel G. Nicastri, Talal El-Hefnawy, Steven J. Hughes, James D. Luketich, Tony E. Godfrey. Optimal Markers for Real-Time Quantitative Reverse Transcription PCR Detection of Circulating Tumor Cells from Melanoma, Breast, Colon, Esophageal, Head and Neck, and Lung Cancers. 2007 Clinical Chemistry, 53(7).
  45. Daniel Nicastri, Tony E. Godfrey and Stephen J. Hughes. Is Occult Lymph Node Disease in Colorectal Cancer Patients Clinically Significant?  A Review of the Relevant Literature. Journal of Molecular Diagnostics; 2007 Nov;9(5):563-71.
  46. MicroRNA Expression Profiles of Esophageal Cancer. Andrew Feber PhD, Liqiang Xi MD, James D. Luketich MD, Arjun Pennathur MD, Rodney J. Landreneau MD, Maoxin Wu MD, Scott J. Swanson MD, Tony E. Godfrey PhD, Virginia R. Litle MD. Journal of Thoracic and Cardiovascular Surgery; 2008 Feb;135(2):255-60.
  47. Identification of cancer-related genes that are alternatively spliced at high frequency in lung adenocarcinoma. Xi, L., Feber, A., Gupta, V. K., Wu, M., Landreaneau, R. J., Litle, V. R., Luketich, J., and Godfrey, T. E. Nucleic Acids Research, October 16 2008 (Epub ahead of print).
  48. Molecular Staging of Pathologically Negative Sentinel Lymph Nodes from Melanoma Patients using Multimarker, Quantitative Real Time RT-PCR. Josep M. Hilari, Cristina Mangas, Liqiang Xi, Cristina Paradelo, Carlos Ferrándiz, Steven J. Hughes, Cindy Yueh, Ivy Altomare, William E. Gooding and Tony E. Godfrey. In Press, Annals of Surgical Oncology 2008.
  49. CCND1 G/A870 Polymorphism Does Not Determine Cyclin D1 Variant Expression in Esophageal Adenocarinoma or Non-Small Cell Lung Cancer. Vanita K. Gupta, Andrew Feber, Liqiang Xi, Arjun Pennathur, Maoxin Wu, James D Luketich, Tony E. Godfrey. In Press; Clinical Cancer Research 2008.
  50. Integrated Genomic Analysis Identifies Therapeutic Targets and Prognostic Markers in Esophageal Adenocarcinoma.  Andrew Feber, Liqiang Xi, Arjun Pennathur, James D. Luketich, Weijia Zhang, Yezhou Sun, Daniel Nicastri, Maoxin Wu, Vanita Gupta, Scott J. Swanson, William E. Gooding, Virginia R. Litle, and Tony E. Godfrey. In review.
  51. A QRT-PCR Assay for Rapid Analysis of Breast Cancer Sentinel Lymph Nodes. Steven J. Hughes, MD, Liqiang Xi, MD, William Gooding, MS, David J. Cole, MD, John Metcalf, MD, Michael Mitas, PhD, Rohit Bhargava, MD, David Dabbs, MD, Jesus Ching, PhD, William McMillan, PhD, and Tony E. Godfrey, PhD. In Review.
  52. Molecular Staging of Occult Nodal Metastases in Esophageal Adenocarcinoma is Predictive of Worse Clinical Outcomes. Ivy Altomare, Arjun Pennathur, Liqiang Xi, Virginia R. Litle, William E. Gooding, James D. Luketich and Tony E. Godfrey. Manuscript in preparation.
  53. MicroRNA Expression Profiles predict outcome in Esophageal Adenocarcinoma. Feber, A., Xi, L., Luketich, J. D., Pennathur, A, Landreaneau, R., Wu, M. H., Swanson S.J, Litle, V.R and Godfrey, T.E. Manuscript in Preparation.
Book Chapters
  1. Hill, C. K. and Godfrey, T. E. Adaptive responses after exposure to low dose radiation. In Edward J.Calabrese (ed.), Biological effects of low level exposures: Dose response relationships., pp. 255-270. Lewis Publishers, 1994.
  2. Development of Quantitative RT-PCR Assays for Measuring Gene Expression Tony E. Godfrey and Lori A. Kelly. Molecular Toxicology Protocols, Humana Press, 2004.
  3.  Godfrey T.E. Intraoperative Molecular Staging of Lymph Nodes. Molecular Foundations in Pathology Series.  2008.
Recent Abstracts
  1. Integrated genomic analysis of esophageal adenocarcinoma using Affymetrix mapping and expression arrays. Feber, A., nicastri, D, Zhang, W., Sun, Y., Wu, M. H., Pennathur, A, Luketich, J. D., Gooding, W, and Godfrey, T. E. 2007 AACR Meeting, Los Angeles CA . 2007.
  2. Clinical significance of genomic alterations in esophageal adenocarcinoma. Feber, A., nicastri, D, Zhang, W., Sun, Y., Wu, M. H., Pennathur, A, Luketich, J. D., Gooding, W, Litle, V. R., and Godfrey, T. E. 2007 AACR Meeting, Los Angeles CA . 2007.
  3. MicroRNA Expression Profiles of Esophageal Cancer. Feber, A., Xi, L., Luketich, J. D., Pennathur, A, Landreaneau, R., Wu, M. H., Swanson SJ, Godfrey, T. E., and Litle, V. R. 2007 American Association for Thoracic Surgery Meeting, Washington DC.  2007.
  4. Identification of cancer-related genes that are alternatively spliced at high frequency in lung adenocarcinoma using whole genome exon arrays. Xi, L., Feber, A., Gupta, V. K., Wu, M., Landreaneau, R. J., Litle, V. R., Luketich, J., and Godfrey, T. E. American Association for Cancer Research Annual Meeting: Proceedings. 4-14-2007.
  5. Molecular Staging of Occult Nodal Metastases in Esophageal Adenocarcinoma is Predictive of Worse Clinical Outcomes. Ivy Altomare, Arjun Pennathur, Liqiang Xi, Virginia R. Litle, William E. Gooding, James D. Luketichŧ and Tony E. Godfrey. ASCO 2007.
  6. CCND1 Polymorphism and Expression in Esophageal Adenocarcinoma. Vanita K. Gupta, Andrew Feber, Liqiang Xi, Arjun Pennathur, Maoxin Wu, James Luketich, Tony E. Godfrey. American Association for Cancer Research Annual Meeting: Proceedings; 2007 Apr 14; Los Angeles, CA. Philadelphia (PA): AACR; 2007.
Invited Presentations at National Conferences and NCI Workshops:

Rapid QRT-PCR for intraoperative evaluation of sentinel lymph nodes.
Featured presentation for Molecular Pathology Program, College of American Pathologists meeting. San Diego, September 14, 2003.

Detection of circulating Tumor cells by RT-PCR. Cancer Biometrics Workshop, International Society for Biological Therapy of Cancer meeting. Washington DC, October 30, 2003.

Intraoperative Analysis of Sentinel Lymph Nodes by Quantitative RT-PCR. United States and Canadian Association of Pathology meeting, San Antonio Texas. February 2005.

Molecular Staging of Sentinel Lymph Nodes. Plenary Session Presentation at the annual Association for Molecular Pathology Meeting, Scottsdale Arizona, November 2005.

Molecular staging of lung and esophageal cancer. Guest speaker at the 2006 meeting of the General Thoracic Surgery Club, Tuscon Arizona.

Integrated Genomic Analysis of esophageal cancer. Guest Speaker at the Oregon Thoracic Society Chest Disease Conference. Sun River Oregon February 2007.

Molecular staging of lung and esophageal cancer. Guest Speaker at the Oregon Thoracic Society Chest Disease Conference. Sun River Oregon February 2007.

Molecular staging of lymph nodes. Invited speaker at the United States and Canadian Academy of Pathology Meeting. San Diego March 2007.

Molecular Staging of Sentinel Nodes. Session Chairperson, Third International Symposium on Sentinel Node Biopsy. Miami Beach, February 2007.

Molecular Staging of Lymph Nodes. Pathology Grand Rounds. Harvard, March 2008.

Peer-reviewed Funding

Active Funding

National Institutes of Health R01 03/09/01-03/31/2010
Use of Quantitative RT-PCR for staging esophageal cancer
(Luketich: Godfrey Co-Investigator)

National Institutes of Health R03 04/01/07-03/31/09
MicroRNA expression in esophageal adenocarcinoma
(Litle: Godfrey Co-Investigator)

National Institutes of Health R21 04/01/08-03/31/10
Standardized NanoArray PCR for Gene Expression Profiling of Lung Cancer
(Godfrey; Multiple PI)

National Institutes of Health R01 09/15/08-07/31/13
Biomarkers for Esophageal Cancer Progression and Prognosis
(Godfrey, PI)

Pending Funding

National Institutes of Health R01 Submitted November 2007
Discovery of novel micoRNAs for therapy, diagnosis and prognosis in NSCLC
(Godfrey)
Priority Score: Pending

National Institutes of Health R21 Submitted June 2007
Micro RNA as a marker for prognosis in esophageal adenocarcinoma
(Godfrey)
Priority Score: 210 (42 percentile). Revision to be submitted March 2008.

Past Funding

National Institutes of Health R01 07/01/02 – 06/30/07
Characterization of the 11q13 amplicon in oral cancer
(Gollin, P.I.; Godfrey, Co-investigator)

National Institutes of Health STTR 05/01/03 – 10/31/05
Automated RNA isolation and RT-PCR for cancer detection.
(Industry PI; Ching: Godfrey University PI)

National Institutes of Health R01 04/01/01-03/31/05*
Use of Quantitative RT-PCR for staging esophageal cancer
(Luketich: Godfrey Co-Investigator)
*Grant renewed until 2010 (see active funding)

National Institutes of Health R01 06/01/02 – 05/30/07
Molecular detection of occult metastases in lung cancer
(Godfrey, P.I.)

National Institutes of Health 1 R01 CA111806-01 04/01/05 – 03/31/08
Title: Molecular Staging of Lymph Nodes in Head and Neck Cancer
(Godfrey, PI)

Patents Genes from the 20q13.2 amplicon and their uses.
United States Patent number 5892010.

A Quantitative PCR method to enumerate DNA copy number.
United States Patent number 6180349.

Multiple mode multiplex reaction quenching method
Patent Pending

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Last Updated: 11/03/2008

Tony E. Godfrey, Ph.D.
Associate Professor of Surgery and Biomedical Genetics



The James P Wilmot Cancer Center
University of Rochester Medical Center
New York, NY



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